Piperazine Erastin

CAS No. 1538593-71-3

Piperazine Erastin( Piperazine-Erastin | Piperazine Erastin | PiperazineErastin )

Catalog No. M12172 CAS No. 1538593-71-3

Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Piperazine Erastin
  • Note
    Research use only, not for human use.
  • Brief Description
    Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
  • Description
    Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
  • In Vitro
    Erastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that is termed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds.
  • In Vivo
    In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration.
  • Synonyms
    Piperazine-Erastin | Piperazine Erastin | PiperazineErastin
  • Pathway
    Apoptosis
  • Target
    Ferroptosis
  • Recptor
    Ferroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1538593-71-3
  • Formula Weight
    645.19084
  • Molecular Formula
    C35H41ClN6O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(C2=CC(CN3CCNCC3)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6
  • Chemical Name
    4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[2-(1-methylethoxy)-5-(1-piperazinylmethyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dixon SJ, et al. Cell. 2012 May 25;149(5):1060-72. 2. Huo H, et al. PLoS One. 2016 May 12;11(5):e0154605.
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