
Piperazine Erastin
CAS No. 1538593-71-3
Piperazine Erastin( Piperazine-Erastin | Piperazine Erastin | PiperazineErastin )
Catalog No. M12172 CAS No. 1538593-71-3
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
Purity : >98% (HPLC)






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Biological Information
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Product NamePiperazine Erastin
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NoteResearch use only, not for human use.
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Brief DescriptionPiperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
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DescriptionPiperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
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In VitroErastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that is termed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds.
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In VivoIn the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration.
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SynonymsPiperazine-Erastin | Piperazine Erastin | PiperazineErastin
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PathwayApoptosis
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TargetFerroptosis
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RecptorFerroptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1538593-71-3
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Formula Weight645.19084
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Molecular FormulaC35H41ClN6O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(C2=CC(CN3CCNCC3)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6
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Chemical Name4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[2-(1-methylethoxy)-5-(1-piperazinylmethyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dixon SJ, et al. Cell. 2012 May 25;149(5):1060-72.
2. Huo H, et al. PLoS One. 2016 May 12;11(5):e0154605.
molnova catalog



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